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diff --git a/px/packages/matrix.scm b/px/packages/matrix.scm
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+(define-module (px packages matrix)
+  #:use-module ((guix licenses) #:prefix license:)
+  #:use-module (gnu packages check)
+  #:use-module (gnu packages databases)
+  #:use-module (gnu packages matrix)
+  #:use-module (gnu packages monitoring)
+  #:use-module (gnu packages python-crypto)
+  #:use-module (gnu packages python-web)
+  #:use-module (gnu packages python-xyz)
+  #:use-module (gnu packages python-build)
+  #:use-module (gnu packages xml)
+  #:use-module (guix build-system python)
+  #:use-module (guix download)
+  #:use-module (guix packages))
+
+(define-public synapse
+  (package
+    (name "synapse")
+    (version "1.45.1")
+    (source (origin
+              (method url-fetch)
+              (uri (pypi-uri "matrix-synapse" version))
+              (sha256
+               (base32
+                "0dmps93cy4b2g73kxvbnsnci1vxj38m2jcaqyxrb9ind0rsik5zi"))))
+    (build-system python-build-system)
+    ;; TODO Run tests with ‘PYTHONPATH=. trial3 tests’.
+    (propagated-inputs
+     `(("python-simplejson" ,python-simplejson) ; not attested but required
+       ;; requirements (synapse/python_dependencies.py)
+       ("python-jsonschema" ,python-jsonschema)
+       ("python-frozendict" ,python-frozendict)
+       ("python-unpaddedbase64" ,python-unpaddedbase64)
+       ("python-canonicaljson" ,python-canonicaljson)
+       ("python-signedjson" ,python-signedjson)
+       ("python-pynacl" ,python-pynacl)
+       ("python-idna" ,python-idna)
+       ("python-service-identity" ,python-service-identity)
+       ("python-twisted" ,python-twisted)
+       ("python-treq" ,python-treq)
+       ("python-pyopenssl" ,python-pyopenssl)
+       ("python-pyyaml" ,python-pyyaml)
+       ("python-pyasn1" ,python-pyasn1)
+       ("python-pyasn1-modules" ,python-pyasn1-modules)
+       ("python-daemonize" ,python-daemonize)
+       ("python-bcrypt" ,python-bcrypt)
+       ("python-pillow" ,python-pillow)
+       ("python-sortedcontainers" ,python-sortedcontainers)
+       ("python-pymacaroons" ,python-pymacaroons)
+       ("python-msgpack" ,python-msgpack)
+       ("python-phonenumbers" ,python-phonenumbers)
+       ("python-six" ,python-six)
+       ("python-prometheus-client" ,python-prometheus-client)
+       ("python-attrs" ,python-attrs)
+       ("python-netaddr" ,python-netaddr)
+       ("python-jinja2" ,python-jinja2)
+       ("python-bleach" ,python-bleach)
+       ("python-typing-extensions" ,python-typing-extensions)
+       ;; conditional requirements (synapse/python_dependencies.py)
+       ;;("python-hiredis" ,python-hiredis)
+       ("python-matrix-synapse-ldap3" ,python-matrix-synapse-ldap3)
+       ("python-psycopg2" ,python-psycopg2)
+       ("python-jinja2" ,python-jinja2)
+       ("python-txacme" ,python-txacme)
+       ("python-pysaml2" ,python-pysaml2)
+       ("python-lxml" ,python-lxml)
+       ("python-packaging" ,python-packaging)
+       ;; sentry-sdk, jaeger-client, and opentracing could be included, but
+       ;; all are monitoring aids and not essential.
+       ("python-pyjwt" ,python-pyjwt)))
+    (native-inputs
+     `(("python-mock" ,python-mock)
+       ("python-parameterized" ,python-parameterized)))
+    (home-page "https://github.com/matrix-org/synapse")
+    (synopsis "Matrix reference homeserver")
+    (description "Synapse is a reference \"homeserver\" implementation of
+Matrix from the core development team at matrix.org, written in
+Python/Twisted.  It is intended to showcase the concept of Matrix and let
+folks see the spec in the context of a codebase and let you run your own
+homeserver and generally help bootstrap the ecosystem.")
+    (license license:asl2.0)))